Lipid Nanoparticles

LNP technology for mRNA and gene therapy delivery

162 companies 23 countries
A

Arrowhead Research

Pasadena, United States

Biopharmaceutical company developing targeted RNAi therapeutics using proprietary TRiM platform

NASDAQ: ARWR
B

BIND Therapeutics

Cambridge, United States

BIND Therapeutics, founded in 2007 and based in Cambridge, Massachusetts, pioneered the Accurin platform of polymeric nanoparticles for targeted cancer drug delivery, representing one of the most advanced clinical applications of nanomedicine. With over $150 million in funding and 100-200 employees, BIND developed sophisticated nanotechnology designed to precisely deliver chemotherapy agents to tumor cells while minimizing systemic toxicity. The company emerged from groundbreaking research at MIT and Harvard on controlled drug delivery using biodegradable polymer nanoparticles. BIND's Accurin nanoparticles were engineered with extraordinary precision, incorporating multiple functional components: a biodegradable polymer core loaded with chemotherapy drugs, a protective hydrophilic polymer shell to evade immune system clearance, and targeting ligands that bind to specific molecules overexpressed on cancer cells. This multicomponent design addressed fundamental challenges in cancer treatment—delivering sufficient drug to tumors while avoiding damage to healthy tissues. The company's lead candidate, BIND-014, consisted of docetaxel chemotherapy encapsulated in nanoparticles displaying PSMA-targeting ligands, designed for prostate cancer treatment. BIND advanced multiple nanoparticle candidates through clinical trials, generating valuable data on nanomedicine performance in humans. The company's clinical programs demonstrated that carefully designed nanoparticles could alter drug biodistribution, enhance tumor accumulation, and potentially improve therapeutic indices. BIND employed sophisticated polymer chemistry and formulation sciences to create nanoparticles with controlled sizes (typically 50-100 nanometers), precise drug loading, and sustained release profiles. The company developed scalable manufacturing processes meeting pharmaceutical GMP standards—a significant achievement given the complexity of multi-functional nanoparticles. Throughout its existence, BIND contributed substantially to understanding how nanoparticle properties including size, surface chemistry, and targeting ligands influence biological fate and therapeutic efficacy. Despite promising preclinical data and successful clinical trial execution, BIND faced challenges common to nanomedicine development including complex regulatory pathways, high development costs, and difficulty demonstrating sufficient therapeutic advantages over existing treatments. In 2016, facing financial pressures, BIND was acquired by Pfizer, which subsequently discontinued the programs, highlighting the challenging economics of nanomedicine development. Nevertheless, BIND's legacy includes important contributions to nanomedicine science, demonstration that sophisticated nanoparticles can be manufactured at pharmaceutical scales, and clinical data advancing understanding of nanoparticle behavior in humans. The company's experience provides valuable lessons for the nanomedicine field regarding the gap between preclinical promise and clinical reality, the importance of selecting appropriate patient populations, and the need for compelling therapeutic differentiation to justify nanomedicine's inherent complexity.

S

Selecta Biosciences

Watertown, United States

Selecta Biosciences, Inc., founded in 2007 and based in Watertown, Massachusetts, is a clinical-stage biopharmaceutical company developing its proprietary ImmTOR nanoparticle platform to address a critical challenge in biologics therapy—unwanted immune responses that reduce treatment efficacy. Publicly traded on NASDAQ (SELB) with over $300 million in funding and 100-200 employees, Selecta has pioneered synthetic vaccine particles (SVP) that can selectively modulate immune responses, potentially enabling repeat administration of therapeutic proteins and gene therapies. The company emerged from research on how nanoparticle properties influence immune system activation, discovering that specific nanoparticle designs could induce immune tolerance rather than immunogenicity. Selecta's ImmTOR platform consists of biodegradable polymer nanoparticles incorporating immunomodulatory small molecules (typically rapamycin analogs) that are taken up by immune cells, inducing tolerance to co-administered therapeutic agents. This approach addresses a major limitation of protein therapeutics and gene therapies—the development of neutralizing antibodies that reduce or eliminate treatment efficacy with repeated dosing. For example, many patients with gout receiving enzyme replacement therapy develop anti-drug antibodies that neutralize the therapeutic enzyme, requiring treatment discontinuation. Selecta's lead program, SEL-212, combines ImmTOR nanoparticles with pegsiticase enzyme therapy for severe gout, with clinical trials demonstrating reduced immunogenicity and improved sustained therapeutic response. The company has expanded its platform to address immunogenicity challenges in gene therapy, where immune responses against viral vectors or therapeutic proteins can limit treatment durability. Selecta has established partnerships with major pharmaceutical companies including Sarepta Therapeutics and Asklepios BioPharmaceutical to apply ImmTOR technology to gene therapy programs for muscular dystrophies and other genetic diseases. The company's nanoparticles are engineered with precise sizes (typically 200-500 nanometers), controlled drug loading, and surface properties optimized for uptake by specific immune cell populations. Selecta has developed manufacturing processes producing clinical-grade ImmTOR nanoparticles at scales required for therapeutic applications, addressing a key challenge in nanomedicine translation. The company's approach represents sophisticated application of nanotechnology principles—using nanoparticle properties to program specific biological responses rather than simply delivering drugs. Selecta's clinical programs have generated important data on how synthetic nanoparticles can modulate human immune systems, contributing to fundamental understanding of nanoparticle immunology. As gene therapies and protein biologics become increasingly important in medicine, addressing immunogenicity challenges will be crucial for enabling repeat dosing and expanding patient populations. Selecta's ImmTOR platform offers a potentially broadly applicable solution to this critical problem, positioning the company at the intersection of nanomedicine and immunotherapy, two of the most promising areas in biopharmaceutical development.

NASDAQ: SELB
N

Nanobio Corporation

Ann Arbor, United States

Developer of nanoemulsion-based products for infection and vaccine delivery

L

Liquidia Technologies

Morrisville, United States

Developer of PRINT technology for precisely engineered drug particles

NASDAQ: LQDA
N

Nanosphere Health Sciences

Vancouver, Canada

Developer of NanoSphere Delivery System for enhanced bioavailability of cannabinoids

M

Moderna

Cambridge, United States

Pioneer in mRNA therapeutics using lipid nanoparticle (LNP) delivery technology for vaccines and medicines

NASDAQ: MRNA
B

BioNTech

Mainz, Germany

Immunotherapy company leveraging lipid nanoparticle delivery for mRNA vaccines and cancer therapies

NASDAQ: BNTX
A

Acuitas Therapeutics

Vancouver, Canada

Leading developer of lipid nanoparticle (LNP) delivery systems for nucleic acid therapeutics, partner for COVID-19 vaccines

P

Precision NanoSystems

Vancouver, Canada

Provider of instruments for scalable nanoparticle manufacturing for gene therapies and mRNA vaccines

A

Alnylam Pharmaceuticals

Cambridge, United States

Pioneer in RNAi therapeutics using lipid nanoparticle delivery for treatment of genetic diseases

NASDAQ: ALNY
I

Intellia Therapeutics

Cambridge, United States

Gene editing company using lipid nanoparticle delivery for in vivo CRISPR therapeutics

NASDAQ: NTLA
E

Evonik Industries

Essen, Germany

Specialty chemicals company and leading producer of fumed silica, precipitated silica, and other nanomaterials

ETR: EVK
N

Nanocure

Tel Aviv, Israel

Nanocure, established in 2015 in Tel Aviv, Israel, is an innovative nanomedicine company focused on developing next-generation cancer therapies through advanced nanoparticle-based drug delivery systems. The company's proprietary platform leverages the unique properties of engineered nanoparticles to achieve precise targeting of cancer cells while minimizing damage to healthy tissue, addressing one of the most significant challenges in oncology treatment. Nanocure's targeted nanoparticle therapeutics are designed to overcome the limitations of conventional chemotherapy, which often causes severe side effects due to non-selective distribution throughout the body. The company's nanoparticle formulations utilize sophisticated surface modifications, including targeting ligands and stealth coatings, to enhance circulation time, improve tumor accumulation through the enhanced permeability and retention effect, and facilitate active targeting to specific cancer cell markers. This multifaceted approach enables higher drug concentrations at tumor sites while reducing systemic exposure and associated toxicities. The technology platform is versatile, capable of encapsulating various therapeutic agents including small molecule drugs, peptides, and nucleic acids, making it applicable to multiple cancer types and treatment modalities. Nanocure's nanoparticles are engineered at the nanoscale (typically 10-200 nanometers) to optimize biological interactions, cellular uptake, and intracellular drug release. The company has secured over $15 million in funding to advance its pipeline through preclinical and clinical development stages. Israel's strong biotechnology ecosystem and expertise in nanomedicine provide Nanocure with access to world-class research facilities, clinical networks, and regulatory support. As cancer treatment increasingly moves toward personalized medicine and targeted therapies, Nanocure's nanoparticle platform represents a significant advancement in delivering more effective and safer cancer treatments, positioning the company as an important player in the rapidly evolving field of cancer nanotherapy.

C

Codiak BioSciences

Cambridge, United States

Codiak BioSciences, founded in 2015 in Cambridge, Massachusetts, is a pioneering biotechnology company at the forefront of exosome-based therapeutics. The company has developed the proprietary engEx platform, which engineers exosomes—naturally occurring nanovesicles (30-150 nanometers) secreted by cells—as sophisticated drug delivery vehicles. Unlike synthetic nanoparticles, exosomes offer inherent biocompatibility, low immunogenicity, and natural ability to cross biological barriers, making them ideal carriers for therapeutic payloads. Codiak's engEx technology precisely modifies exosomes to display specific targeting molecules on their surface while loading therapeutic cargo inside, creating programmable nanomedicines with enhanced tissue specificity and therapeutic efficacy. The company's lead programs include exoSTING, an exosome-delivered STING agonist for cancer immunotherapy, and exoIL-12, which delivers interleukin-12 for tumor treatment. These engineered exosomes leverage the body's natural intercellular communication system to deliver potent immunomodulatory agents directly to target cells, potentially revolutionizing cancer treatment with improved safety profiles compared to conventional delivery methods. Codiak has raised over $300 million in funding, reflecting significant investor confidence in exosome therapeutics. The Cambridge location places Codiak at the heart of the biotech innovation ecosystem, with access to world-renowned research institutions and clinical infrastructure. The company employs between 100-200 specialists in molecular biology, nanotechnology, and clinical development. Exosomes represent a convergence of cell biology and nanotechnology, and Codiak's platform addresses critical challenges in drug delivery including tumor penetration, immune evasion, and payload stability. As the field of nanomedicine evolves beyond synthetic nanoparticles, Codiak's focus on biological nanovesicles positions it as a leader in next-generation therapeutic delivery, with potential applications extending beyond oncology to neurodegenerative diseases, rare disorders, and vaccines.

N

Nanexa

Uppsala, Sweden

Developer of PharmaShell nanocoating technology for controlled drug release

NGM: NANEXA
N

NanoVation Therapeutics

Vancouver, Canada

Developer of next-generation lipid nanoparticle delivery systems for RNA therapeutics

V

Verve Therapeutics

Boston, United States

Gene editing company using lipid nanoparticle delivery for cardiovascular disease treatment

NASDAQ: VERV
C

CureVac

Tubingen, Germany

Pioneer in mRNA technology using lipid nanoparticle delivery for vaccines and therapeutics

NASDAQ: CVAC
G

Genevant Sciences

Cambridge, United States

Developer of lipid nanoparticle and ligand conjugate delivery systems for genetic medicines

A

Arcturus Therapeutics

San Diego, United States

Developer of LUNAR lipid nanoparticle delivery platform for mRNA medicines

NASDAQ: ARCT
S

Silence Therapeutics

London, United Kingdom

Pioneer in precision RNAi medicines using mRNAi GOLD platform with GalNAc delivery

NASDAQ: SLN
D

Dicerna Pharmaceuticals

Lexington, United States

Developer of GalXC RNAi platform for targeted gene silencing therapeutics

N

NanoCarrier

Kashiwa, Japan

Developer of micellar nanoparticle drug delivery systems for cancer treatment

TSE: 4571
N

Nippon Kayaku

Tokyo, Japan

Pharmaceutical and chemical company with nanomedicine portfolio including micellar formulations

TSE: 4272
N

NanoMedSyn

Montpellier, France

Developer of MUSIC nanoparticle platform for targeted drug delivery

N

Nanovex Biotechnologies

Oviedo, Spain

Biotech company developing extracellular vesicle and exosome-based delivery systems

A

Arrowhead Pharmaceuticals

Pasadena, United States

Leader in RNAi therapeutics using targeted delivery

NASDAQ: ARWR public
N

NanoMedica

San Diego, United States

Developer of nanoparticle-based cancer therapeutics

N

Nanoform Finland

Helsinki, Finland

Developer of controlled expansion of supercritical solutions for drug nanoforming

NASDAQ Helsinki: NANOFH public
T

Translate Bio

Lexington, United States

mRNA therapeutics company with proprietary LNP technology, acquired by Sanofi

E

Etherna Immunotherapies

Niel, Belgium

mRNA immunotherapy company with proprietary LNP delivery technology

e

eTheRNA Immunotherapies

Niel, Belgium

mRNA immunotherapy with proprietary delivery platform

M

Mina Therapeutics

London, United Kingdom

Small activating RNA therapeutics with LNP delivery

T

Tidal Therapeutics

Cambridge, United States

LNP-based in vivo gene therapy for immune cells, acquired by Sanofi

R

ReNAgade Therapeutics

Cambridge, United States

RNA delivery technology for extrahepatic targets

S

SciSparc

Tel Aviv, Israel

Nano-drug delivery for CNS disorders

NASDAQ: SPRC public
N

Nano Therapeutics

Mumbai, India

Nano-based drug delivery systems for cancer therapy

N

Nanovetores

Florianópolis, Brazil

Nanoencapsulation technology for cosmetics

N

NanoBio (BlueWillow Biologics)

Ann Arbor, United States

Nanoemulsion-based vaccines and therapeutics

E

Evonik Nano

Essen, Germany

Fumed silica and specialty nanomaterials

XETRA: EVK public
N

NanoTherapeutics

Alachua, United States

Biopharmaceutical nanotechnology development

N

NanoImaging Services

San Diego, United States

Cryo-EM and negative stain imaging

N

Nanoform

Helsinki, Finland

Controlled expansion of supercritical solutions for drug nanoparticle engineering

Nasdaq Nordic: NANOFH public
A

Abraxis BioScience

Los Angeles, United States

Pioneer of nanoparticle albumin-bound (nab) technology for cancer drugs

N

NanoCarrier Co., Ltd.

Chiba, Japan

Polymeric micellar nanoparticle drug delivery for cancer therapeutics

TSE: 4571 public
L

LNP Japan

Tokyo, Japan

Lipid nanoparticle manufacturing services for RNA therapeutics

S

Starpharma

Melbourne, Australia

Dendrimer nanotechnology for antiviral and oncology therapeutics

ASX: SPL public
N

NanoBio Corporation

Ann Arbor, United States

Nanoemulsion technology for intranasal vaccines and skin treatments

N

Nanobio2Pharma

Bordeaux, France

Nanoparticle drug formulation and CDMO services

N

Nanomerics

London, United Kingdom

Molecular envelope technology for enhanced drug delivery

E

Evonik Industries

Essen, Germany

Fumed silica nanoparticles and specialty chemicals

Frankfurt: EVK public
W

Wacker Chemie

Munich, Germany

Silicones, polysilicon, and specialty chemicals

Frankfurt: WCH public
C

Camurus

Lund, Sweden

FluidCrystal lipid-based drug delivery systems

Nasdaq Stockholm: CAMX public
E

Ethris GmbH

Planegg, Germany

SNIM RNA stabilized mRNA therapeutics

E

Entos Pharmaceuticals

Edmonton, Canada

Fusogenix nucleic acid delivery platform

A

Arrowhead Pharmaceuticals

Pasadena, United States

TRiM RNAi therapeutics platform

NASDAQ: ARWR public
P

Phio Pharmaceuticals

Marlborough, United States

INTASYL self-delivering RNAi technology

NASDAQ: PHIO public
T

Takeda Pharmaceutical

Tokyo, Japan

Global pharma with nanomedicine programs

NYSE: TAK public
S

Shionogi & Co.

Osaka, Japan

Infectious disease pharma with nanoparticle research

TSE: 4507 public
O

Otsuka Pharmaceutical

Tokyo, Japan

CNS and oncology pharma with nanomedicine development

TSE: 4578 public
L

LG Chem Life Sciences

Seoul, South Korea

Life sciences division with nanoparticle drug delivery

KRX: 051910 public
S

Samyang Biopharmaceuticals

Seoul, South Korea

Genexol-PM polymeric micelle nanoparticle drugs

KRX: 000070 public
H

Hanmi Pharmaceutical

Seoul, South Korea

LAPSCOVERY long-acting drug delivery platform

KRX: 128940 public
Y

Yuhan Corporation

Seoul, South Korea

Korean pharma with nanoformulation programs

KRX: 000100 public
C

CSPC Pharmaceutical

Shijiazhuang, China

Major Chinese pharma with nanomedicine research

HKEX: 1093 public
H

Hansoh Pharmaceutical

Lianyungang, China

Innovative Chinese pharma with nanoformulation expertise

HKEX: 3692 public
Z

Zhejiang Medicine

Shaoxing, China

API manufacturer with nano-formulation capabilities

SSE: 600216 public
A

Asymchem Laboratories

Tianjin, China

CDMO services including nanoparticle formulations

HKEX: 6821 public
L

Livzon Pharmaceutical

Zhuhai, China

Chinese pharma with microsphere and nanoparticle delivery

SZSE: 000513 public
L

Luye Pharma Group

Yantai, China

Advanced drug delivery including microspheres and liposomes

HKEX: 2186 public
T

Taiwan Liposome Company

Taipei, Taiwan

BioSeizer and NanoX liposomal drug delivery platforms

TWSE: 4152 public
P

PharmaEngine

Taipei, Taiwan

Liposomal formulations for cancer treatment

TWSE: 4162 public
C

Celsion Corporation

Lawrenceville, United States

ThermoDox heat-activated liposomal doxorubicin

NASDAQ: CLSN public
O

Oncobiologics

Cranbury, United States

Biosimilar development with advanced formulation technology

S

Sixfold Bioscience

London, United Kingdom

AI-driven nanoparticle delivery optimization

N

Nano Biotecnologia SA

São Paulo, Brazil

Nanotechnology for cosmetic and pharmaceutical applications

L

Lonza

Basel, Switzerland

Life sciences and specialty ingredients

SIX: LONN public
C

CR Micro

Wuxi, China

Power semiconductor foundry

SSE STAR: 688396 public
A

Alnylam Pharmaceuticals

Cambridge, United States

Leader in RNAi therapeutics using lipid nanoparticle delivery for genetic diseases

NASDAQ: ALNY public
A

Arbutus Biopharma

Vancouver, Canada

Develops lipid nanoparticle technology for hepatitis B and other infectious diseases

NASDAQ: ABUS public
A

Arcturus Therapeutics

San Diego, United States

RNA medicines company using LUNAR lipid nanoparticle delivery platform

NASDAQ: ARCT public
A

Acuitas Therapeutics

Vancouver, Canada

Develops lipid nanoparticle delivery systems for nucleic acid therapeutics

G

Genevant Sciences

Cambridge, United States

Lipid nanoparticle and ligand conjugate delivery platforms for genetic medicines

V

Verve Therapeutics

Cambridge, United States

Gene editing company for cardiovascular disease using base editing and LNP delivery

NASDAQ: VERV public
A

Arrowhead Pharmaceuticals

Pasadena, United States

RNAi therapeutics company developing targeted delivery systems for genetic medicines

NASDAQ: ARWR public
D

Dicerna Pharmaceuticals

Lexington, United States

RNAi therapeutics using GalXC delivery platform for liver-targeted gene silencing

C

Celator Pharmaceuticals

Vancouver, Canada

Liposomal nanoparticle drug delivery for combination cancer therapies

L

Lipocine

Salt Lake City, United States

Lipid-based oral drug delivery platform for poorly bioavailable compounds

NASDAQ: LPCN public
L

Liquidia Technologies

Morrisville, United States

PRINT nanoparticle technology for precisely engineered drug particles

NASDAQ: LQDA public
N

Novavax

Gaithersburg, United States

Recombinant nanoparticle vaccine technology for infectious diseases

NASDAQ: NVAX public
V

Vaxart

South San Francisco, United States

Oral vaccine platform using recombinant vectors and nanoparticle technology

NASDAQ: VXRT public
A

Afrigen Biologics

Cape Town, South Africa

African mRNA vaccine hub developing lipid nanoparticle delivery technology

S

Serum Institute of India

Pune, India

World's largest vaccine manufacturer exploring nanoparticle vaccine technology

S

SK Bioscience

Seongnam, South Korea

Vaccine and biopharmaceutical company with nanoparticle vaccine capabilities

KRX: 302440 public
P

Particle Sciences

Bethlehem, United States

Drug delivery and formulation development including nanoparticle systems

C

Catalent

Somerset, United States

Contract manufacturer with lipid nanoparticle and advanced drug delivery capabilities

NYSE: CTLT public
L

Lonza Pharma

Basel, Switzerland

Life sciences company with lipid nanoparticle manufacturing for mRNA therapeutics

SIX: LONN public
E

Evonik Health Care

Essen, Germany

Specialty chemicals for pharmaceutical drug delivery including lipid nanoparticles

XETRA: EVK public
C

Croda Health Care

Snaith, United Kingdom

Specialty ingredients including lipids for nanoparticle drug delivery

LSE: CRDA public
C

Curia Global

Albany, United States

Contract research and manufacturing with nanoparticle drug delivery expertise

H

Hovione

Loures, Portugal

CDMO with spray-dried nanoparticle and amorphous dispersion technologies

P

Piramal Pharma Solutions

Mumbai, India

CDMO with capabilities in lipid nanoparticle and advanced drug delivery systems

NSE: PPLPHARMA public
S

Siegfried Holding

Zofingen, Switzerland

Pharmaceutical CDMO with particle engineering and formulation capabilities

SIX: SFZN public
R

Recipharm

Stockholm, Sweden

Contract manufacturer with inhaled nanoparticle and specialty drug delivery

C

Corden Pharma

Basel, Switzerland

CDMO specializing in lipids and lipid nanoparticle manufacturing

E

Exelead

Indianapolis, United States

CDMO focused on liposomes and lipid nanoparticle drug delivery systems

T

T&T Scientific

Knoxville, United States

Liposome and lipid nanoparticle preparation equipment and services

P

Polymun Scientific

Klosterneuburg, Austria

CDMO specializing in liposomal and lipid nanoparticle formulations

E

Encapsula NanoSciences

Brentwood, United States

Custom liposome and nanoparticle formulation services and products

F

FormuMax Scientific

Sunnyvale, United States

Liposome products and custom lipid nanoparticle formulation services

N

Northern Lipids

Vancouver, Canada

CDMO for liposomal and lipid nanoparticle drug delivery formulations

L

Lipoid GmbH

Ludwigshafen, Germany

Manufacturer of high-purity phospholipids for drug delivery and diagnostics

A

Avanti Polar Lipids

Alabaster, United States

High-purity lipids and liposomes for research and drug delivery applications

N

NOF Corporation

Tokyo, Japan

PEG-lipid conjugates and functional lipids for liposome drug delivery

TSE: 4403 public
M

Merck Life Science

Darmstadt, Germany

Life science products including lipids and nanomaterials for drug delivery research

XETRA: MRK public
N

Nanocs

New York, United States

PEGylation reagents and functionalized nanoparticles for biomedical applications

E

Evonik Health Care

Essen, Germany

Drug delivery polymers and lipid nanoparticle components

XETRA: EVK public
A

Alnylam Pharmaceuticals

Cambridge, United States

Pioneer in RNAi therapeutics with lipid nanoparticle delivery

NASDAQ: ALNY public
P

Passage Bio

Philadelphia, United States

AAV gene therapies for CNS diseases with novel delivery

NASDAQ: PASG public
4

4D Molecular Therapeutics

Emeryville, United States

Therapeutic vectors using Directed Evolution AAV capsid discovery

NASDAQ: FDMT public
S

Spark Therapeutics

Philadelphia, United States

Gene therapy pioneer (Luxturna) now part of Roche

G

Generation Bio

Cambridge, United States

Non-viral gene therapy using lipid nanoparticle delivery

NASDAQ: GBIO public
D

Dicerna Pharmaceuticals

Lexington, United States

RNAi therapeutics using GalNAc delivery (acquired by Novo Nordisk)

C

Curia Global

Albany, United States

CDMO with nanoparticle and complex formulation capabilities

C

Croda International

Snaith, United Kingdom

Specialty chemicals with Avanti lipids for LNP formulations

LSE: CRDA public
E

Entos Pharmaceuticals

Edmonton, Canada

Fusogenix DNA delivery platform for gene therapy

K

Kernal Biologics

Cambridge, United States

Self-amplifying mRNA with immune-silent delivery

L

Laronde

Cambridge, United States

Endless RNA (eRNA) technology for persistent protein expression

O

Orna Therapeutics

Cambridge, United States

Circular RNA platform for cell therapy and protein replacement

C

Chimeron Bio

Philadelphia, United States

Chimeric viral vectors for improved gene therapy delivery

E

Entrada Therapeutics

Boston, United States

Endosomal Escape Vehicle (EEV) platform for intracellular delivery

NASDAQ: TRDA public
S

Sorrento Therapeutics

San Diego, United States

Biopharmaceutical with ADC and nanoparticle delivery platforms

A

Applied Genetic Technologies

Alachua, United States

AAV gene therapies for rare ophthalmologic diseases

NASDAQ: AGTC public
M

MeiraGTx

New York, United States

Gene therapy for inherited retinal diseases and beyond

NASDAQ: MGTX public
S

Sarepta Therapeutics

Cambridge, United States

Gene therapy and RNA therapeutics for muscular dystrophies

NASDAQ: SRPT public
S

Solid Biosciences

Charlestown, United States

Gene therapy for Duchenne muscular dystrophy

NASDAQ: SLDB public
L

Lysogene

Paris, France

CNS-targeted gene therapy for lysosomal storage diseases

Euronext: LYS public
F

Freeline Therapeutics

Stevenage, United Kingdom

AAV gene therapy for liver-targeted diseases

NASDAQ: FRLN public
V

Vertex Pharmaceuticals

Boston, United States

Global biotechnology company focused on cystic fibrosis and gene editing therapies

NASDAQ: VRTX public
C

Catalent Cell and Gene

Somerset, United States

Global CDMO offering cell therapy, gene therapy, and viral vector manufacturing

O

Oxford Biomedica

Oxford, United Kingdom

Gene and cell therapy group specializing in lentiviral vector development and manufacturing

LSE: OXB public
L

Lexeo Therapeutics

New York, United States

Gene therapy company developing treatments for cardiac and neurological diseases

NASDAQ: LXEO public
E

Evonik Performance Materials

Essen, Germany

Specialty chemicals company providing high-performance materials and nano solutions

XETRA: EVK public
N

Nanomi

Oldenzaal, Netherlands

Membrane emulsification for nanoparticle production

A

ARIZ Precision Medicine

San Diego, United States

Nanotechnology for targeted cancer drug delivery using siRNA nanoparticles

M

Madrigal Mental Care

Boston, United States

Organic nanoparticle drug delivery for mental health

A

Aurora Biosynthetics

Singapore, Singapore

GMP manufacturing of plasmid DNA, mRNA and lipid nanoparticles for Asia Pacific

M

Mepsgen

Seoul, South Korea

NanoCalibur automated nanoparticle production using microfluidic technology

C

Cour Pharmaceutical

Chicago, United States

Particle platforms enabling immune targeting for inflammatory and immune applications

Z

Zylo Therapeutics

Minneapolis, United States

Sustained-release drug-delivery system using hydrogel-derived nanoparticles

i

iCeutica

Sydney, Australia

Encapsulated Organic Nanoparticles (EON) platform for nano-sized drug particles

H

Helex

Boston, United States

Lipid nanoparticle technology for targeted drug delivery for kidney diseases

M

Meda Biotech

Shanghai, China

Hybrid-nanoengineered water soluble drugs optimizing drug trafficking to disease sites

B

Blueberry Therapeutics

Manchester, United Kingdom

Polymer nanoparticles for treating fungal infections with 83% efficacy

C

Cello Therapeutics

San Diego, United States

Cell membrane-coated nanoparticles for immunotherapy delivery with FDA IND status

H

HK Inno.N

Seoul, South Korea

Pharmaceutical nanotechnology for drug delivery systems

E

Evox Therapeutics

Oxford, United Kingdom

DeliverEX platform for engineered exosome therapeutics

E

ExonanoRNA

Boston, United States

RNA nanoparticles and exosomes for cancer therapeutics

P

Phosphorex

Hopkinton, United States

CDMO for lipid nanoparticle and liposome drug delivery

D

DIVERSA Technologies

Santiago de Compostela, Spain

Innovative nanoparticle formulations for drug delivery

D

DIANT Pharma

San Diego, United States

LiFT continuous manufacturing system for lipid nanoparticles at GMP scale