Nanosequencing
Nanopore and other nanoscale DNA/RNA sequencing
NanoString Technologies
Seattle, United States
Life sciences company developing tools for gene expression analysis using nanoparticle-based molecular barcoding technology
Lux Capital
New York, United States
Venture capital firm investing in deep technology including nanotechnology
Exosome Diagnostics
Waltham, United States
Exosome Diagnostics, founded in 2008 in Waltham, Massachusetts, emerged as a global leader in exosome-based liquid biopsy technology before being acquired by Bio-Techne Corporation. The company pioneered the use of exosomes—nanoscale extracellular vesicles (30-150 nm) naturally released by cells—as biomarkers for non-invasive disease detection and monitoring. Exosomes contain genetic material, proteins, and other molecular cargo that reflect the state of their cell of origin, making them valuable diagnostic tools for cancer and other diseases. Exosome Diagnostics developed sophisticated isolation and analysis technologies to capture these nanovesicles from bodily fluids and extract clinically relevant biomarkers, particularly RNA and DNA molecules. The company's flagship product, the ExoDx Prostate Test (IntelliScore), represents a breakthrough in prostate cancer detection, analyzing exosomal RNA from urine samples to help determine the need for prostate biopsy, thereby reducing unnecessary invasive procedures. This non-invasive approach leverages the natural biology of exosomes, which are shed into circulation and easily accessible through liquid biopsies. Exosome Diagnostics also developed comprehensive exosome isolation kits enabling researchers and clinicians to harness these nanosized vesicles for biomarker discovery and diagnostic applications. The company raised over $100 million in funding and established strategic partnerships with pharmaceutical companies and research institutions. The acquisition by Bio-Techne expanded the reach of exosome diagnostics technology within a larger life sciences organization. Exosome-based diagnostics represent a paradigm shift from traditional tissue biopsies to liquid biopsies, offering less invasive, repeatable testing that can track disease progression and treatment response. As precision medicine advances, exosome diagnostics continues to play a crucial role in enabling earlier disease detection, personalized treatment selection, and real-time monitoring, establishing exosomes as a transformative platform in nano-diagnostics and molecular medicine.
10x Genomics
Pleasanton, United States
10x Genomics, founded in 2012 in Pleasanton, California, has revolutionized biological research through innovative microfluidic and nanoscale technologies that enable unprecedented resolution in genomics analysis. The company went public on NASDAQ under ticker TXG, reflecting its status as a major player in the genomics technology sector with over 1,000 employees worldwide. 10x Genomics specializes in single-cell analysis and spatial biology, utilizing sophisticated nanofluidic systems that manipulate individual cells and molecules within nanoliter-scale droplets and nanofabricated chambers. The company's flagship Chromium platform employs microfluidic partitioning to isolate individual cells into nanoliter-sized gel beads in emulsion (GEMs), where each cell receives a unique molecular barcode. This nanotechnology-enabled approach allows researchers to analyze gene expression, immune repertoires, and epigenetic states at single-cell resolution, revealing cellular heterogeneity previously obscured in bulk tissue analysis. The Visium spatial genomics platform combines tissue imaging with transcriptomics, using nanoscale capture arrays to map gene expression while preserving spatial context within tissue sections. The newer Xenium in situ platform pushes resolution further, enabling subcellular visualization of hundreds of genes simultaneously through multiplexed in situ hybridization with nanoscale precision. These technologies rely on advanced nanofabrication techniques, precise microfluidic control, and molecular barcoding strategies that operate at nanometer scales. 10x Genomics products have become essential tools in cancer research, immunology, neuroscience, and developmental biology, enabling discoveries about cellular diversity, disease mechanisms, and therapeutic targets. The company's success demonstrates how nanotechnology enables transformative advances in life sciences, making previously impossible measurements routine. With continued innovation in nanofluidics, molecular barcoding, and imaging technologies, 10x Genomics continues to expand the frontiers of biological understanding at the single-cell and subcellular levels.
Twist Bioscience
South San Francisco, United States
Twist Bioscience, founded in 2013 in South San Francisco, California, has revolutionized DNA synthesis through its innovative silicon-based nanoscale manufacturing platform. Trading on NASDAQ under ticker TWST, the company employs 500-1000 people and represents a convergence of semiconductor nanotechnology and synthetic biology. Twist's proprietary synthesis platform miniaturizes traditional DNA synthesis chemistry onto silicon chips using semiconductor photolithography and nanofabrication techniques, enabling massively parallel synthesis of oligonucleotides in nanoscale wells. This breakthrough reduces reagent consumption by over 1000-fold compared to conventional column-based synthesis while dramatically increasing throughput and reducing costs. The silicon-based approach allows Twist to synthesize millions of distinct DNA sequences simultaneously on a single chip, with each synthesis occurring in nanoliter or picoliter reaction volumes. The company's core products include custom synthetic genes, gene fragments, oligonucleotide pools, and next-generation sequencing libraries used in drug discovery, agricultural biotechnology, industrial chemicals production, and academic research. Twist has pioneered applications in DNA data storage, leveraging the massive information density of DNA molecules to archive digital data at nanoscale dimensions, with potential to revolutionize long-term data storage. The platform enables rapid design-build-test cycles for synthetic biology applications, accelerating development of therapeutic antibodies, enzymes, and novel biomolecules. Twist's nanotechnology-enabled manufacturing approach addresses the growing demand for synthetic DNA across biotechnology sectors, supporting applications from CRISPR gene editing to vaccine development. The company's success demonstrates how semiconductor nanofabrication techniques can transform biological manufacturing, creating a scalable, high-precision platform for the programmable synthesis of genetic material. As synthetic biology continues to expand, Twist's nanomanufacturing capabilities position it as critical infrastructure for biotechnology innovation, enabling researchers and companies worldwide to access high-quality synthetic DNA quickly and affordably.
Oxford Nanopore Technologies
Oxford, United Kingdom
Pioneer in nanopore DNA/RNA sequencing technology enabling real-time, long-read sequencing
Pacific Biosciences
Menlo Park, United States
Developer of single molecule real-time (SMRT) DNA sequencing technology
Illumina
San Diego, United States
Global leader in DNA sequencing using nanoscale flow cell technology
NanoString Technologies
Seattle, United States
Developer of molecular barcoding technology for gene expression analysis
Pacific Biosciences
Menlo Park, United States
Developer of SMRT sequencing using zero-mode waveguides
Singular Genomics
La Jolla, United States
Next-gen sequencing platform with nanoscale engineering
Nabsys
Providence, United States
Developer of electronic genome mapping using nanochannels
Quantum Biosystems
Tokyo, Japan
Single-molecule electrical sequencing technology
Quantum-Si
Branford, United States
Single-molecule protein sequencing
Ionis Pharmaceuticals
Carlsbad, United States
Antisense oligonucleotide therapeutics for genetic diseases
Editas Medicine
Cambridge, United States
CRISPR-based medicines for genetic diseases including eye disorders
DNA Script
Paris, France
Enzymatic DNA synthesis for on-demand oligo production
Standard BioTools
South San Francisco, United States
Microfluidics and mass cytometry for life science research
Symrise
Holzminden, Germany
Fragrances, flavors, and cosmetic ingredients
Editas Medicine
Cambridge, United States
Genome editing company using CRISPR with lipid nanoparticle delivery systems
Ionis Pharmaceuticals
Carlsbad, United States
Pioneer in antisense technology and RNA-targeted therapeutics
Exiqon
Vedbaek, Denmark
Locked nucleic acid technology for RNA research and diagnostics
Akadeum Life Sciences
Ann Arbor, United States
Microbubble technology for fast, gentle cell separation and enrichment
Guardant Health
Redwood City, United States
Liquid biopsy for cancer detection using circulating tumor DNA analysis
GRAIL
Menlo Park, United States
Multi-cancer early detection using cell-free DNA and advanced sequencing
Foundation Medicine
Cambridge, United States
Comprehensive genomic profiling for cancer using advanced sequencing
Tempus
Chicago, United States
AI-driven precision medicine with genomic sequencing and diagnostics
Natera
Austin, United States
Cell-free DNA testing for prenatal screening and cancer detection
Invitae
San Francisco, United States
Genetic testing company with comprehensive hereditary cancer panels
Myriad Genetics
Salt Lake City, United States
Molecular diagnostics for hereditary cancer and prenatal screening
Color Health
Burlingame, United States
Population-scale genetic testing and COVID-19 testing infrastructure
23andMe
Sunnyvale, United States
Consumer genetics company with health and ancestry DNA testing
Ancestry
Lehi, United States
Family history and consumer DNA testing using advanced genotyping
BGI Genomics
Shenzhen, China
Genomics company with sequencing platforms and diagnostic services
Berry Genomics
Beijing, China
Non-invasive prenatal testing and genetic diagnostics in China
Annoroad Gene Technology
Beijing, China
Genomic sequencing services and bioinformatics solutions
Burning Rock Biotech
Guangzhou, China
Cancer genomics and liquid biopsy diagnostics company in China
Singlera Genomics
Shanghai, China
DNA methylation-based early cancer detection and liquid biopsy
MGI Tech
Shenzhen, China
DNA sequencing instruments and reagents using proprietary technology
Twist Bioscience
South San Francisco, United States
Silicon-based DNA synthesis platform for synthetic biology
Nautilus Biotechnology
Seattle, United States
Single-molecule proteomics platform for comprehensive protein analysis
Nanopore Technologies
Oxford, United Kingdom
Nanopore-based DNA/RNA sequencing with portable devices
Element Biosciences
San Diego, United States
Benchtop DNA sequencing with accuracy at scale
Ultima Genomics
Newark, United States
Ultra-low-cost genome sequencing technology
NanoCellect Biomedical
San Diego, United States
Microfluidic cell sorting for single-cell applications
RainDance Technologies (Bio-Rad)
Billerica, United States
Droplet digital PCR technology, acquired by Bio-Rad
Passage Bio
Philadelphia, United States
AAV gene therapies for CNS diseases with novel delivery
Regenxbio
Rockville, United States
AAV gene therapy using NAV Technology Platform
Synthego
Redwood City, United States
CRISPR reagent supplier and genome engineering platform
Caribou Biosciences
Berkeley, United States
Clinical-stage CRISPR genome editing company developing transformative therapies
Absci
Vancouver, United States
Generative AI drug creation company designing and validating novel biologic drugs
Molecular Assemblies
San Diego, United States
Enzymatic DNA synthesis company enabling rapid gene synthesis and DNA data storage
Catalog Technologies
Boston, United States
DNA data storage company developing massive-scale digital data storage in DNA
Charles River Cell Solutions
Wilmington, United States
Contract research organization providing cell and gene therapy development services
Rocket Pharmaceuticals
Cranbury, United States
Gene therapy company developing treatments for rare childhood diseases
Neurogene
New York, United States
Gene therapy company developing treatments for rare neurological diseases in children
Abbott Laboratories
Abbott Park, United States
Global healthcare company with diagnostics and medical device solutions
Qiagen
Hilden, Germany
Provider of sample to insight solutions for molecular diagnostics
Veracyte
South San Francisco, United States
Genomic diagnostics company improving cancer diagnosis and treatment
CareDx
Brisbane, United States
Precision medicine company focused on transplant diagnostics
Adaptive Biotechnologies
Seattle, United States
Biotechnology company developing immune-driven medicine through sequencing
Benson Hill
St. Louis, United States
Food tech company using CropOS platform to develop better plant genetics
MyFitnessPal
Baltimore, United States
Nutrition tracking and fitness app with food database
TrainHeroic
Denver, United States
Strength and conditioning platform for coaches and athletes
Trace Genomics
San Francisco, United States
Soil microbiome testing and analytics
Biome Makers
West Sacramento, United States
Soil and plant microbiome intelligence
Dapper Labs
Vancouver, Canada
Sports NFTs and blockchain
Glint
Sunnyvale, United States
Employee engagement platform
Nava PBC
Washington, United States
Public benefit corporation for government technology
NanoString Technologies
Seattle, United States
Molecular barcode technology for gene expression analysis
Bionano Genomics
San Diego, United States
Genome analysis tools using nanochannel technology