Synthetic Biology
Engineering biological systems at the nanoscale
10x Genomics
Pleasanton, United States
10x Genomics, founded in 2012 in Pleasanton, California, has revolutionized biological research through innovative microfluidic and nanoscale technologies that enable unprecedented resolution in genomics analysis. The company went public on NASDAQ under ticker TXG, reflecting its status as a major player in the genomics technology sector with over 1,000 employees worldwide. 10x Genomics specializes in single-cell analysis and spatial biology, utilizing sophisticated nanofluidic systems that manipulate individual cells and molecules within nanoliter-scale droplets and nanofabricated chambers. The company's flagship Chromium platform employs microfluidic partitioning to isolate individual cells into nanoliter-sized gel beads in emulsion (GEMs), where each cell receives a unique molecular barcode. This nanotechnology-enabled approach allows researchers to analyze gene expression, immune repertoires, and epigenetic states at single-cell resolution, revealing cellular heterogeneity previously obscured in bulk tissue analysis. The Visium spatial genomics platform combines tissue imaging with transcriptomics, using nanoscale capture arrays to map gene expression while preserving spatial context within tissue sections. The newer Xenium in situ platform pushes resolution further, enabling subcellular visualization of hundreds of genes simultaneously through multiplexed in situ hybridization with nanoscale precision. These technologies rely on advanced nanofabrication techniques, precise microfluidic control, and molecular barcoding strategies that operate at nanometer scales. 10x Genomics products have become essential tools in cancer research, immunology, neuroscience, and developmental biology, enabling discoveries about cellular diversity, disease mechanisms, and therapeutic targets. The company's success demonstrates how nanotechnology enables transformative advances in life sciences, making previously impossible measurements routine. With continued innovation in nanofluidics, molecular barcoding, and imaging technologies, 10x Genomics continues to expand the frontiers of biological understanding at the single-cell and subcellular levels.
Twist Bioscience
South San Francisco, United States
Twist Bioscience, founded in 2013 in South San Francisco, California, has revolutionized DNA synthesis through its innovative silicon-based nanoscale manufacturing platform. Trading on NASDAQ under ticker TWST, the company employs 500-1000 people and represents a convergence of semiconductor nanotechnology and synthetic biology. Twist's proprietary synthesis platform miniaturizes traditional DNA synthesis chemistry onto silicon chips using semiconductor photolithography and nanofabrication techniques, enabling massively parallel synthesis of oligonucleotides in nanoscale wells. This breakthrough reduces reagent consumption by over 1000-fold compared to conventional column-based synthesis while dramatically increasing throughput and reducing costs. The silicon-based approach allows Twist to synthesize millions of distinct DNA sequences simultaneously on a single chip, with each synthesis occurring in nanoliter or picoliter reaction volumes. The company's core products include custom synthetic genes, gene fragments, oligonucleotide pools, and next-generation sequencing libraries used in drug discovery, agricultural biotechnology, industrial chemicals production, and academic research. Twist has pioneered applications in DNA data storage, leveraging the massive information density of DNA molecules to archive digital data at nanoscale dimensions, with potential to revolutionize long-term data storage. The platform enables rapid design-build-test cycles for synthetic biology applications, accelerating development of therapeutic antibodies, enzymes, and novel biomolecules. Twist's nanotechnology-enabled manufacturing approach addresses the growing demand for synthetic DNA across biotechnology sectors, supporting applications from CRISPR gene editing to vaccine development. The company's success demonstrates how semiconductor nanofabrication techniques can transform biological manufacturing, creating a scalable, high-precision platform for the programmable synthesis of genetic material. As synthetic biology continues to expand, Twist's nanomanufacturing capabilities position it as critical infrastructure for biotechnology innovation, enabling researchers and companies worldwide to access high-quality synthetic DNA quickly and affordably.
Beam Therapeutics
Cambridge, United States
Pioneer in base editing using lipid nanoparticle delivery for precision genetic medicines
Strand Therapeutics
Boston, United States
Programmable mRNA therapeutics with logic gates
Prime Medicine
Cambridge, United States
Prime editing therapeutics with LNP delivery
Novozymes
Bagsværd, Denmark
Industrial enzymes and microorganisms at nanoscale
Egyptian Nanotechnology Society
Cairo, Egypt
Egypt's nanotechnology research network
CRISPR Therapeutics
Zug, Switzerland
CRISPR-based gene editing therapeutics for blood disorders and cancer
Ginkgo Bioworks
Boston, United States
Cell programming platform for bio-based products and materials
DNA Script
Paris, France
Enzymatic DNA synthesis for on-demand oligo production
Nuclera
Cambridge, United Kingdom
Desktop protein synthesis and bioprinting technology
Sphere Fluidics
Cambridge, United Kingdom
Picodroplet microfluidics for single-cell analysis and antibody discovery
NanoSyrinx
Sheffield, United Kingdom
Bacterial contractile injection system for protein delivery
Symrise
Holzminden, Germany
Fragrances, flavors, and cosmetic ingredients
23andMe
Sunnyvale, United States
Consumer genetics company with health and ancestry DNA testing
Ancestry
Lehi, United States
Family history and consumer DNA testing using advanced genotyping
BGI Genomics
Shenzhen, China
Genomics company with sequencing platforms and diagnostic services
MGI Tech
Shenzhen, China
DNA sequencing instruments and reagents using proprietary technology
Kyoto University Nano
Kyoto, Japan
Leading Japanese university with iCeMS nanobio research
Twist Bioscience
South San Francisco, United States
Silicon-based DNA synthesis platform for synthetic biology
Nautilus Biotechnology
Seattle, United States
Single-molecule proteomics platform for comprehensive protein analysis
Element Biosciences
San Diego, United States
Benchtop DNA sequencing with accuracy at scale
Ultima Genomics
Newark, United States
Ultra-low-cost genome sequencing technology
Replicate Bioscience
San Diego, United States
Self-replicating RNA therapeutics platform
Synthego
Redwood City, United States
CRISPR reagent supplier and genome engineering platform
Sherlock Biosciences
Cambridge, United States
CRISPR-based molecular diagnostics platform
Poseida Therapeutics
San Diego, United States
Gene editing and CAR-T cell therapy using piggyBac system
Organovo
San Diego, United States
3D bioprinting pioneer developing human tissues for drug discovery and therapeutic applications
Prellis Biologics
San Francisco, United States
Holographic bioprinting for vascularized tissues and organs at high speed and resolution
Koniku
San Jose, United States
Wetware company merging synthetic biology with silicon for neuromorphic computing
Legend Biotech
Somerset, United States
Global biotechnology company developing novel cell therapies for oncology
Caribou Biosciences
Berkeley, United States
Clinical-stage CRISPR genome editing company developing transformative therapies
Century Therapeutics
Philadelphia, United States
Biotechnology company developing iPSC-derived allogeneic cell therapies for cancer
Codexis
Redwood City, United States
Enzyme engineering company developing biocatalysts for pharmaceutical manufacturing
Zymergen
Emeryville, United States
Biofacturing company engineering microbes for advanced materials
Absci
Vancouver, United States
Generative AI drug creation company designing and validating novel biologic drugs
Evonetix
Cambridge, United Kingdom
DNA synthesis company using semiconductor technology for desktop DNA writing
Molecular Assemblies
San Diego, United States
Enzymatic DNA synthesis company enabling rapid gene synthesis and DNA data storage
Catalog Technologies
Boston, United States
DNA data storage company developing massive-scale digital data storage in DNA
LogicBio Therapeutics
Lexington, United States
Genome editing company developing gene insertion medicines for pediatric diseases
Sana Biotechnology
Seattle, United States
Biotechnology company engineering cells to treat disease using in vivo and ex vivo approaches
Carbios
Clermont-Ferrand, France
Biotech company developing enzymatic solutions for plastic and textile recycling
LanzaTech
Skokie, United States
Carbon recycling company converting emissions to sustainable products
Impossible Foods
Redwood City, United States
Plant-based meat company using heme protein technology to replicate meat flavor
Beyond Meat
El Segundo, United States
Plant-based meat company with products designed to replicate animal protein
Upside Foods
Berkeley, United States
Cultivated meat company growing real meat directly from animal cells
GOOD Meat
Alameda, United States
Eat Just subsidiary producing cultivated chicken meat approved for sale
Aleph Farms
Rehovot, Israel
Cultivated steak company growing beef directly from non-GMO cells
Mosa Meat
Maastricht, Netherlands
Cultivated beef company from the creator of the first cultured hamburger
SuperMeat
Tel Aviv, Israel
Cultivated chicken company developing cell-cultured poultry
Finless Foods
Emeryville, United States
Cultivated seafood company growing bluefin tuna from cells
BlueNalu
San Diego, United States
Cultivated seafood company producing cell-based fish products
Wildtype
San Francisco, United States
Cultivated salmon company growing sushi-grade salmon from cells
Perfect Day
Berkeley, United States
Precision fermentation company producing animal-free dairy proteins
New Culture
San Francisco, United States
Precision fermentation company producing animal-free mozzarella cheese
Clara Foods
San Francisco, United States
Precision fermentation company producing animal-free egg proteins
Motif FoodWorks
Boston, United States
Food ingredient company using biotech to create meat and dairy alternatives
Nature's Fynd
Chicago, United States
Fermentation company producing Fy protein from fungi discovered in Yellowstone
Air Protein
San Mateo, United States
Company making protein from air using NASA-inspired technology
Solar Foods
Helsinki, Finland
Finnish company producing Solein protein from CO2 and electricity
Oatly
Malmö, Sweden
Swedish oat milk company pioneering plant-based dairy alternatives
Ripple Foods
Emeryville, United States
Pea protein milk company providing sustainable dairy alternatives
NotCo
Santiago, Chile
AI-powered food company creating plant-based products using Giuseppe AI
Bowery Farming
New York, United States
Vertical farming company using proprietary operating system for indoor agriculture
Gotham Greens
Brooklyn, United States
Urban greenhouse company operating rooftop and indoor farms
Indigo Agriculture
Boston, United States
Agricultural technology company using plant microbiome for crop improvement
Pivot Bio
Berkeley, United States
Microbial nitrogen company providing biological nitrogen fixation for crops
Ginkgo Bioworks Agriculture
Boston, United States
Ginkgo Bioworks agriculture division engineering microbes for farming
Benson Hill
St. Louis, United States
Food tech company using CropOS platform to develop better plant genetics
Pairwise
Durham, United States
Gene editing company developing better fruits and vegetables using CRISPR
Inari Agriculture
Cambridge, United States
Seed design company using gene editing for sustainable crop improvement
Syngenta
Basel, Switzerland
Global agriculture company providing seeds and crop protection
Tyson Ventures
Springdale, United States
Tyson Foods venture capital arm investing in food technology innovation
Oscar Health
New York, United States
Technology-focused health insurance company with member-centric approach
Bolt Threads
Emeryville, United States
Biotechnology company creating sustainable materials inspired by nature
Modern Meadow
Nutley, United States
Biofabrication company creating sustainable leather alternatives
Spiber
Tsuruoka, Japan
Japanese biotechnology company producing protein-based materials
Genomatica
San Diego, United States
Biotechnology company producing sustainable chemicals and materials
Kitman Labs
Dublin, Ireland
Sports science and injury prevention analytics platform
Zone7
San Francisco, United States
AI-powered injury prediction and prevention platform
MyFitnessPal
Baltimore, United States
Nutrition tracking and fitness app with food database
Noom
New York, United States
Behavior change platform for weight loss and health
Eat Just
San Francisco, United States
Plant-based egg and cultivated meat company
Meati Foods
Boulder, United States
Mycelium-based meat alternative company
Motif FoodWorks
Boston, United States
Food ingredient company improving plant-based products
Indigo Agriculture
Boston, United States
Agricultural technology company using microbiology and carbon credits
Plenty
South San Francisco, United States
Vertical farming company growing produce indoors
Bowery Farming
New York, United States
Indoor vertical farming company with proprietary OS
Prospera Technologies
Tel Aviv, Israel
AI and computer vision for agriculture
Granular
San Francisco, United States
Farm management software platform
Ynsect
Evry, France
Insect farming company producing protein from mealworms
InnovaFeed
Paris, France
Insect protein producer for aquaculture and pet food
Bright Health
Minneapolis, United States
Health insurance company partnering with care delivery systems
Devoted Health
Waltham, United States
Medicare Advantage plans with technology-driven care model
Vice Media
Brooklyn, United States
Youth media company with digital, TV, and film content
TrainHeroic
Denver, United States
Strength and conditioning platform for coaches and athletes
Califia Farms
Los Angeles, United States
Plant-based beverage company specializing in oat and almond milk products
Good Catch
New York, United States
Plant-based seafood company making fish alternatives from legumes
Meati Foods
Boulder, United States
Mushroom root mycelium company creating whole-cut meat alternatives
Remilk
Tel Aviv, Israel
Precision fermentation company producing animal-free dairy proteins
Trace Genomics
San Francisco, United States
Soil microbiome testing and analytics
Biome Makers
West Sacramento, United States
Soil and plant microbiome intelligence
Joyn Bio
Boston, United States
Engineered microbes for nitrogen fixation
Kula Bio
Somerville, United States
Biological nitrogen for sustainable farming
Factor
Chicago, United States
Chef-prepared meal delivery
Wyzant
Chicago, United States
Online tutoring marketplace
Outschool
San Francisco, United States
Live online classes marketplace
BetterUp
San Francisco, United States
Coaching and mental fitness platform
Nava PBC
Washington, United States
Public benefit corporation for government technology
Cargill RegenConnect
Minneapolis, United States
Regenerative agriculture program
Agrinos
Davis, United States
Biological crop inputs
Gym Pass
New York, United States
Corporate fitness and wellness platform
Misfits Market
Delanco, United States
Affordable organic groceries
Daily Harvest
New York, United States
Frozen plant-based foods
Exsilio Therapeutics
Boston, United States
mRNA platform for revocable genetic medicines
Cellino
Cambridge, United States
AI-guided laser platform for personalized cell therapy manufacturing
Nanollose
Perth, Australia
Tree-free nanocellulose fibers from waste for sustainable textiles