Protein Nanoparticles
Engineered protein-based nanoparticles for drug delivery
Selecta Biosciences
Watertown, United States
Selecta Biosciences, Inc., founded in 2007 and based in Watertown, Massachusetts, is a clinical-stage biopharmaceutical company developing its proprietary ImmTOR nanoparticle platform to address a critical challenge in biologics therapy—unwanted immune responses that reduce treatment efficacy. Publicly traded on NASDAQ (SELB) with over $300 million in funding and 100-200 employees, Selecta has pioneered synthetic vaccine particles (SVP) that can selectively modulate immune responses, potentially enabling repeat administration of therapeutic proteins and gene therapies. The company emerged from research on how nanoparticle properties influence immune system activation, discovering that specific nanoparticle designs could induce immune tolerance rather than immunogenicity. Selecta's ImmTOR platform consists of biodegradable polymer nanoparticles incorporating immunomodulatory small molecules (typically rapamycin analogs) that are taken up by immune cells, inducing tolerance to co-administered therapeutic agents. This approach addresses a major limitation of protein therapeutics and gene therapies—the development of neutralizing antibodies that reduce or eliminate treatment efficacy with repeated dosing. For example, many patients with gout receiving enzyme replacement therapy develop anti-drug antibodies that neutralize the therapeutic enzyme, requiring treatment discontinuation. Selecta's lead program, SEL-212, combines ImmTOR nanoparticles with pegsiticase enzyme therapy for severe gout, with clinical trials demonstrating reduced immunogenicity and improved sustained therapeutic response. The company has expanded its platform to address immunogenicity challenges in gene therapy, where immune responses against viral vectors or therapeutic proteins can limit treatment durability. Selecta has established partnerships with major pharmaceutical companies including Sarepta Therapeutics and Asklepios BioPharmaceutical to apply ImmTOR technology to gene therapy programs for muscular dystrophies and other genetic diseases. The company's nanoparticles are engineered with precise sizes (typically 200-500 nanometers), controlled drug loading, and surface properties optimized for uptake by specific immune cell populations. Selecta has developed manufacturing processes producing clinical-grade ImmTOR nanoparticles at scales required for therapeutic applications, addressing a key challenge in nanomedicine translation. The company's approach represents sophisticated application of nanotechnology principles—using nanoparticle properties to program specific biological responses rather than simply delivering drugs. Selecta's clinical programs have generated important data on how synthetic nanoparticles can modulate human immune systems, contributing to fundamental understanding of nanoparticle immunology. As gene therapies and protein biologics become increasingly important in medicine, addressing immunogenicity challenges will be crucial for enabling repeat dosing and expanding patient populations. Selecta's ImmTOR platform offers a potentially broadly applicable solution to this critical problem, positioning the company at the intersection of nanomedicine and immunotherapy, two of the most promising areas in biopharmaceutical development.
NanoViricides
Shelton, United States
Developer of nanoviricide drugs designed to attack and destroy viruses
Nanosphere Health Sciences
Vancouver, Canada
Developer of NanoSphere Delivery System for enhanced bioavailability of cannabinoids
Tarveda Therapeutics
Watertown, United States
Developer of miniature drug conjugates for targeted cancer therapy
NanoXact
San Diego, United States
Brand offering precisely manufactured nanoparticles for life science applications
NanoLight Technologies
Pinetop, United States
NanoLight Technologies, founded in 1995 in Pinetop, Arizona, is a specialized manufacturer of advanced bioluminescent and fluorescent nanoparticle probes for biological research and imaging applications. With nearly three decades of experience, the company has become a trusted supplier of high-quality molecular imaging reagents that enable researchers to visualize biological processes at the cellular and molecular levels. NanoLight's flagship NanoLuc technology represents a breakthrough in bioluminescent reporters, offering one of the smallest and brightest bioluminescent proteins available for research applications. This engineered luciferase enzyme, when combined with its substrate coelenterazine, produces intense luminescence that enables sensitive detection of cellular events, protein interactions, and gene expression with minimal background interference. The company's coelenterazine substrates, available in multiple variants optimized for different applications, serve as essential reagents for numerous bioluminescence-based assays. These small molecule substrates are chemically synthesized to high purity standards, ensuring reliable performance in demanding research applications. NanoLight also manufactures fluorescent nanoparticle probes that leverage quantum confinement effects and surface chemistry modifications to create bright, photostable markers for cellular imaging, flow cytometry, and immunoassays. These nanoparticles, typically ranging from 10-100 nanometers in diameter, offer advantages over conventional organic dyes including enhanced brightness, resistance to photobleaching, and tunable emission wavelengths. The company's products support diverse research areas including cancer biology, neuroscience, drug discovery, and infectious disease research. As a privately-held company with 10-50 employees, NanoLight maintains close relationships with the research community, providing technical support and custom synthesis services. The company's contribution to nanotechnology lies in developing and manufacturing nanoscale imaging tools that make invisible biological processes visible, accelerating scientific discovery across life sciences disciplines.
Nippon Kayaku
Tokyo, Japan
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Nanovex Biotechnologies
Oviedo, Spain
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Wyatt Technology
Santa Barbara, United States
US manufacturer of light scattering instruments for nanoparticle characterization
SandboxAQ
Palo Alto, United States
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Aquaporin A/S
Kongens Lyngby, Denmark
Pioneer in biomimetic water filtration using aquaporin proteins
NanoMedica
San Diego, United States
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Nanoform Finland
Helsinki, Finland
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NanoMedTrix
Berlin, Germany
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Exicure
Chicago, United States
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Nano Therapeutics
Mumbai, India
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L'Oréal Nano
Paris, France
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Nanovetores
Florianópolis, Brazil
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Nanoimmunotech
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Quantum-Si
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Ann Arbor, United States
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NanoImaging Services
San Diego, United States
Cryo-EM and negative stain imaging
Nanoform
Helsinki, Finland
Controlled expansion of supercritical solutions for drug nanoparticle engineering
Celgene (Bristol-Myers Squibb)
Summit, United States
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Abraxis BioScience
Los Angeles, United States
Pioneer of nanoparticle albumin-bound (nab) technology for cancer drugs
BioDynamics Laboratory
Tokyo, Japan
Nanogel and polymer technology for drug delivery applications
Nanomerics
London, United Kingdom
Molecular envelope technology for enhanced drug delivery
Midatech Pharma
Abingdon, United Kingdom
Gold nanoparticle drug conjugates for oncology therapeutics
Ceramisphere
Sydney, Australia
Ceramic nanoparticle drug delivery systems
Ajinomoto Bio-Pharma Services
San Diego, United States
CDMO for oligonucleotides and ADCs
Daiichi Sankyo
Tokyo, Japan
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Eisai Co.
Tokyo, Japan
Neurology and oncology with nanoformulation research
LG Chem Life Sciences
Seoul, South Korea
Life sciences division with nanoparticle drug delivery
Samyang Biopharmaceuticals
Seoul, South Korea
Genexol-PM polymeric micelle nanoparticle drugs
Celltrion
Incheon, South Korea
Biosimilars and antibody drug conjugates
Daewoong Pharmaceutical
Seoul, South Korea
Innovative drug delivery and biologics
WuXi AppTec
Shanghai, China
Global CRO/CDMO with nanomedicine manufacturing capabilities
Asymchem Laboratories
Tianjin, China
CDMO services including nanoparticle formulations
Livzon Pharmaceutical
Zhuhai, China
Chinese pharma with microsphere and nanoparticle delivery
Oncobiologics
Cranbury, United States
Biosimilar development with advanced formulation technology
NanoSyrinx
Sheffield, United Kingdom
Bacterial contractile injection system for protein delivery
University of São Paulo Nanomedicine
São Paulo, Brazil
Nanomedicine research at South America's largest university
Symrise
Holzminden, Germany
Fragrances, flavors, and cosmetic ingredients
Selecta Biosciences
Watertown, United States
ImmTOR biodegradable nanoparticles for immune tolerance induction
Halozyme Therapeutics
San Diego, United States
ENHANZE technology enabling subcutaneous delivery of biologics
Lipocine
Salt Lake City, United States
Lipid-based oral drug delivery platform for poorly bioavailable compounds
Novavax
Gaithersburg, United States
Recombinant nanoparticle vaccine technology for infectious diseases
Vaxart
South San Francisco, United States
Oral vaccine platform using recombinant vectors and nanoparticle technology
Serum Institute of India
Pune, India
World's largest vaccine manufacturer exploring nanoparticle vaccine technology
Bharat Biotech
Hyderabad, India
Vaccine developer with nanoparticle-based vaccine platforms
SK Bioscience
Seongnam, South Korea
Vaccine and biopharmaceutical company with nanoparticle vaccine capabilities
Particle Sciences
Bethlehem, United States
Drug delivery and formulation development including nanoparticle systems
Curia Global
Albany, United States
Contract research and manufacturing with nanoparticle drug delivery expertise
Polymun Scientific
Klosterneuburg, Austria
CDMO specializing in liposomal and lipid nanoparticle formulations
Lipoid GmbH
Ludwigshafen, Germany
Manufacturer of high-purity phospholipids for drug delivery and diagnostics
BioVision
Milpitas, United States
Life science reagents including nanoparticle-based assays and detection kits
Creative Diagnostics
Shirley, United States
Diagnostic reagents including gold and magnetic nanoparticles for lateral flow assays
Nanocs
New York, United States
PEGylation reagents and functionalized nanoparticles for biomedical applications
Spherotech
Lake Forest, United States
Microspheres and nanoparticles for flow cytometry, diagnostics, and research
Bangs Laboratories
Fishers, United States
Microspheres and polymer beads for diagnostics and flow cytometry
Beckman Coulter Diagnostics
Brea, United States
Clinical diagnostics with nanoparticle-based immunoassays and flow cytometry
Bio-Techne
Minneapolis, United States
Life science tools including nanoparticle-based reagents and spatial biology
PerkinElmer
Waltham, United States
Analytical instruments and diagnostics with nanoparticle-based assay technologies
Sartorius
Göttingen, Germany
Bioprocess and lab equipment with nanofiltration and membrane technology
BBI Solutions
Cardiff, United Kingdom
Gold nanoparticles and reagents for in-vitro diagnostics
Refeyn
Oxford, United Kingdom
Mass photometry for label-free protein characterization
Denali Therapeutics
South San Francisco, United States
Neurodegeneration drugs using Transport Vehicle BBB-crossing technology
Voyager Therapeutics
Cambridge, United States
AAV capsid engineering for CNS gene therapy delivery
4D Molecular Therapeutics
Emeryville, United States
Therapeutic vectors using Directed Evolution AAV capsid discovery
Bluebird Bio
Somerville, United States
Gene therapy using lentiviral vectors for genetic diseases
Curia Global
Albany, United States
CDMO with nanoparticle and complex formulation capabilities
Chimeron Bio
Philadelphia, United States
Chimeric viral vectors for improved gene therapy delivery
Bicycle Therapeutics
Cambridge, United Kingdom
Bicyclic peptide platform for targeted drug delivery
PeptiDream
Kawasaki, Japan
Peptide Drug Discovery Platform System for macrocyclic therapeutics
Sorrento Therapeutics
San Diego, United States
Biopharmaceutical with ADC and nanoparticle delivery platforms
Mersana Therapeutics
Cambridge, United States
Antibody drug conjugates using Dolasynthen platform
ADC Therapeutics
Lausanne, Switzerland
Antibody drug conjugates for hematological malignancies
Seagen
Bothell, United States
ADC pioneer (Adcetris, Padcev) acquired by Pfizer
ImmunoGen
Waltham, United States
ADC technology company acquired by AbbVie
Synaffix
Amsterdam, Netherlands
ADC technology platform using GlycoConnect and toxSYN
Sutro Biopharma
South San Francisco, United States
Cell-free protein synthesis for site-specific ADC conjugation
Bioasis Technologies
Guilford, Canada
xB3 platform for blood-brain barrier crossing drug delivery
AngioChem
Montreal, Canada
Peptide-drug conjugates for CNS delivery across BBB
Annexon Biosciences
Brisbane, United States
Complement cascade inhibitors for neurological diseases
Regenxbio
Rockville, United States
AAV gene therapy using NAV Technology Platform
MeiraGTx
New York, United States
Gene therapy for inherited retinal diseases and beyond
Krystal Biotech
Pittsburgh, United States
Gene therapies using HSV-1 vectors for skin diseases
Sarepta Therapeutics
Cambridge, United States
Gene therapy and RNA therapeutics for muscular dystrophies
Solid Biosciences
Charlestown, United States
Gene therapy for Duchenne muscular dystrophy
Ultragenyx Pharmaceutical
Novato, United States
Gene therapy and biologics for rare genetic diseases
Rocket Pharmaceuticals
Cranbury, United States
Lentiviral and AAV gene therapies for rare diseases
Genethon
Evry, France
Non-profit gene therapy research laboratory
Freeline Therapeutics
Stevenage, United Kingdom
AAV gene therapy for liver-targeted diseases
Orchard Therapeutics
London, United Kingdom
Hematopoietic stem cell gene therapy for rare diseases
BICO Group (Cellink)
Gothenburg, Sweden
Life science technology with bioprinting and bioinks for tissue engineering and drug discovery
Ultragenyx Pharmaceutical
Novato, United States
Biopharmaceutical company developing novel products for rare and ultra-rare diseases
Biomarin Pharmaceutical
San Rafael, United States
Global biotechnology company developing therapies for rare genetic diseases
Vertex Pharmaceuticals
Boston, United States
Global biotechnology company focused on cystic fibrosis and gene editing therapies
Bristol Myers Squibb Cell Therapy
Summit, United States
Global biopharmaceutical company with leading CAR T cell therapy franchise
Legend Biotech
Somerset, United States
Global biotechnology company developing novel cell therapies for oncology
Allogene Therapeutics
South San Francisco, United States
Clinical-stage biotechnology company pioneering allogeneic CAR T cell therapies
Lyell Immunopharma
South San Francisco, United States
T cell reprogramming company developing next-generation cell therapies for solid tumors
Adicet Bio
Menlo Park, United States
Clinical-stage biotechnology company developing allogeneic gamma delta T cell therapies
Daiichi Sankyo ADC
Tokyo, Japan
Global pharmaceutical company with leading ADC technology platform
Exelixis
Alameda, United States
Oncology company developing transformative cancer treatments
Resilience
San Diego, United States
Biomanufacturing company building sustainable network for complex medicine production
Catalent Cell and Gene
Somerset, United States
Global CDMO offering cell therapy, gene therapy, and viral vector manufacturing
WuXi Advanced Therapies
Shanghai, China
Global contract development and manufacturing organization for advanced therapies
uniQure
Amsterdam, Netherlands
Gene therapy company developing AAV-based treatments for severe genetic diseases
Rocket Pharmaceuticals
Cranbury, United States
Gene therapy company developing treatments for rare childhood diseases
Asklepios BioPharmaceutical
Research Triangle Park, United States
Gene therapy company developing AAV-based treatments for genetic diseases
Abeona Therapeutics
New York, United States
Clinical-stage biopharmaceutical company developing gene therapies for rare diseases
Lexeo Therapeutics
New York, United States
Gene therapy company developing treatments for cardiac and neurological diseases
Neurogene
New York, United States
Gene therapy company developing treatments for rare neurological diseases in children
Sana Biotechnology
Seattle, United States
Biotechnology company engineering cells to treat disease using in vivo and ex vivo approaches
Taysha Gene Therapies
Dallas, United States
Gene therapy company developing treatments for monogenic CNS diseases
Beyond Meat
El Segundo, United States
Plant-based meat company with products designed to replicate animal protein
Perfect Day
Berkeley, United States
Precision fermentation company producing animal-free dairy proteins
Clara Foods
San Francisco, United States
Precision fermentation company producing animal-free egg proteins
Motif FoodWorks
Boston, United States
Food ingredient company using biotech to create meat and dairy alternatives
Nature's Fynd
Chicago, United States
Fermentation company producing Fy protein from fungi discovered in Yellowstone
Air Protein
San Mateo, United States
Company making protein from air using NASA-inspired technology
Solar Foods
Helsinki, Finland
Finnish company producing Solein protein from CO2 and electricity
Ripple Foods
Emeryville, United States
Pea protein milk company providing sustainable dairy alternatives
Mori
Boston, United States
Food preservation company using silk protein coating technology
Tyson Ventures
Springdale, United States
Tyson Foods venture capital arm investing in food technology innovation
ADM
Chicago, United States
Global food processing and ingredients company with alternative protein investments
Cargill
Wayzata, United States
Global food corporation with significant investments in food technology and alternatives
Ingredion
Westchester, United States
Ingredients company providing starches, sweeteners, and plant-based solutions
Kerry Group
Tralee, Ireland
Irish food ingredients company providing taste and nutrition solutions
Bolt Threads
Emeryville, United States
Biotechnology company creating sustainable materials inspired by nature
Modern Meadow
Nutley, United States
Biofabrication company creating sustainable leather alternatives
Eat Just
San Francisco, United States
Plant-based egg and cultivated meat company
Indigo Agriculture
Boston, United States
Agricultural technology company using microbiology and carbon credits
Ynsect
Evry, France
Insect farming company producing protein from mealworms
InnovaFeed
Paris, France
Insect protein producer for aquaculture and pet food
Califia Farms
Los Angeles, United States
Plant-based beverage company specializing in oat and almond milk products
Good Catch
New York, United States
Plant-based seafood company making fish alternatives from legumes
Agrinos
Davis, United States
Biological crop inputs
Nanotope
Evanston, United States
Self-assembling peptide nanomaterials
Nanoligent
Leuven, Belgium
Oncology nanodrug development
Exsilio Therapeutics
Boston, United States
mRNA platform for revocable genetic medicines
Cour Pharmaceutical
Chicago, United States
Particle platforms enabling immune targeting for inflammatory and immune applications
Revalesio Corporation
Tacoma, United States
Oxygen delivery technology at nano-scale for therapeutic applications
BioPact
Delft, Netherlands
Nanoformulation technology for drug delivery applications
Mulder Lab
Eindhoven, Netherlands
Nanomedicine research and development services
Poly-Dtech
Strasbourg, France
Fluorescent nanoparticle-based immunoassays and lateral flow tests for biomarker detection
Adocia
Lyon, France
BioChaperone nanoformulation technology for improved insulin delivery
Tandem Nano
Boston, United States
Nanoformulation delivery solutions for agriculture and pharmaceuticals
Evox Therapeutics
Oxford, United Kingdom
DeliverEX platform for engineered exosome therapeutics
Aruna Bio
Athens, United States
Neural-derived exosomes for CNS drug delivery crossing BBB
BioMagnetic Solutions
State College, United States
Magnetic nanoparticle solutions for bioseparation and diagnostics
Micromod Partikeltechnologie
Rostock, Germany
Magnetic micro and nanoparticles for life science applications