NanoLight Technologies

About

NanoLight Technologies, founded in 1995 in Pinetop, Arizona, is a specialized manufacturer of advanced bioluminescent and fluorescent nanoparticle probes for biological research and imaging applications. With nearly three decades of experience, the company has become a trusted supplier of high-quality molecular imaging reagents that enable researchers to visualize biological processes at the cellular and molecular levels. NanoLight's flagship NanoLuc technology represents a breakthrough in bioluminescent reporters, offering one of the smallest and brightest bioluminescent proteins available for research applications. This engineered luciferase enzyme, when combined with its substrate coelenterazine, produces intense luminescence that enables sensitive detection of cellular events, protein interactions, and gene expression with minimal background interference. The company's coelenterazine substrates, available in multiple variants optimized for different applications, serve as essential reagents for numerous bioluminescence-based assays. These small molecule substrates are chemically synthesized to high purity standards, ensuring reliable performance in demanding research applications. NanoLight also manufactures fluorescent nanoparticle probes that leverage quantum confinement effects and surface chemistry modifications to create bright, photostable markers for cellular imaging, flow cytometry, and immunoassays. These nanoparticles, typically ranging from 10-100 nanometers in diameter, offer advantages over conventional organic dyes including enhanced brightness, resistance to photobleaching, and tunable emission wavelengths. The company's products support diverse research areas including cancer biology, neuroscience, drug discovery, and infectious disease research. As a privately-held company with 10-50 employees, NanoLight maintains close relationships with the research community, providing technical support and custom synthesis services. The company's contribution to nanotechnology lies in developing and manufacturing nanoscale imaging tools that make invisible biological processes visible, accelerating scientific discovery across life sciences disciplines.